Refinement of Clinical Management of Patients with Gastrointestinal Cancer
Refinement of Clinical Management of Patients with Gastrointestinal Cancer
Project number : 252082
Created by: Daniel Giglio, 2018-08-12
Last revised by: Daniel Giglio, 2018-08-12
Project created in: FoU i Region Halland

PublishedPublished

1. Projektbeskrivning

Sammanfattning av projektet (Vetenskaplig eller Populärvetenskaplig)

Appendiceal tumours are rare tumours often discovered at appendectomy due to appendicitis. We will assess whether tumour-infiltrating lymphocytes (TILs) may predict tumour recurrence and overall survival (OS) in appendiceal tumours. Oxaliplatin is an effective cytostatic drug used for patients with tumours in the gastrointestinal tract. We will here assess whether cooling of hands with pre-cooled mitts and of feet with pre-cooled slippers may reduce oxaliplatin-induced neuropathy and if this may prolong the duration of use of oxaliplatin for palliative gastrointestinal cancer patients. Targeted therapy against epidermal growth factor receptor (EGFr) and vascular epidermal growth factor (VEGF), respectively, is also used in the treatment of colorectal cancer. The drugs are expensive and treatment traditions vary in Sweden in when the drugs are introduced in the palliative setting. We will retroperspectivally assess how OS is affected if these drugs are introduced as first, second or later lines of therapies. Patients with end-of-life cancer disease often visit emergency departments and are exposed to potentially excessive medical and surgical interventions. We will assess the degree of patients visiting emergency departments and whether patients have been in contact with health care units for symptoms that later have resulted in acute admissions. We will identify strategies to prevent unnecessary visits of emergency departments and hospitalizaton.

2. Information om forskargruppen

Medarbetare i projektet

Bengt Nilsson
Kirurgi
Stefan Lindskog
avd för Endokrin- och Sarkomkirurgi, Sahlgrenska och Kirurgen, Hallands Sjukhus, Varberg
Katarina Engström
Kirurgkliniken

3. Information om projektet

Status på projektet

Påbörjat/Pågående

Projektets startdatum

2019-01-01

Projektets slutdatum

2022-01-01

Huvudsakligt ämnesområde för projektet (SCB klassificering)

Cancer och onkologi

MeSH-termer för att beskriva ämnesområdet

information Added MeSH terms
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Palliative Care
Care alleviating symptoms without curing the underlying disease. (Stedman, 25th ed)
Drug Costs
The amount that a health care institution or organization pays for its drugs. It is one component of the final price that is charged to the consumer (FEES, PHARMACEUTICAL or PRESCRIPTION FEES).
Polyneuropathies
Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.
Medical Oncology
A subspecialty of internal medicine concerned with the study of neoplasms.
Immune System
The body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components.

Arbetsplatser involverade i projektet

information Added workplaces
Landsting - Region Halland - Hallands sjukhus - Område 3 - Kirurgikliniken Hallands sjukhus - Onkologimottagning Kirurgi Varberg
Landsting - Region Halland - Hallands sjukhus - Område 3 - Kirurgikliniken Hallands sjukhus - Läkare Kirurgi Varberg

Refinement of Clinical Management of Patients with Gastrointestinal Cancer, from FoU i Region Halland
http://www.researchweb.org/is/fouhalland/project/252082