PURE-HF
PURE-HF
Project number : 254341
Created by: Karin Björling, 2018-10-23
Project created in: Centrum för Klinisk Forskning Dalarna

PublishedPublished

Grundläggande information om projektet

Fullständig titel

PURE-HF: Peripheral Ultrafiltration for the RElief From Congestion in Heart Failure

Startdatum

2018-01-01

Beräknat slutdatum

2021-12-31

Ämnesområde

not checked Cancer
checked Cirkulation och andning
not checked Endokrinologi och metabolism
not checked Gynekologi
not checked Infektion
not checked Kirurgi
not checked Ortopedi
not checked Reumatologi
not checked Psykiatri
not checked Medicintekniska produkter
not checked Annat

Information inblandande personer och organisationer

Sammanfattning

This study evaluates whether tailored, peripheral ultrafiltration complementary to low-dose diuretics is associated with a reduction in cardiovascular mortality in 90 days after randomization and heart failure events in 90 days after discharge than usual care including stepped intravenous diuretics in acutely decompensated chronic heart failure with fluid overload (not fully responsive to diuretic therapy).
The study will evaluate whether stepped, peripheral ultrafiltration complementary to low-dose diuretics influences 90-day clinical outcomes compared to usual care including intravenous diuretics in symptomatic heart failure patients with persistent congestion. Hospitalized subjects will be randomly assigned to receive either a tailored, peripheral ultrafiltration approach complementary to intravenous low-dose diuretics and other guideline-directed medical therapy OR high-dose diuretic therapy and other Guideline-directed medical therapy.

Klinik

Kardiologkliniken, Falun

Typ av studie

not checked Klinisk prövning (Clinical Trial)
not checked Klinisk prövning, fas I (Clinical Trial Phase I)
not checked Klinisk prövning, fas II (Clinical Trial Phase II)
not checked Klinisk prövning, fas III (Clinical Trial Phase III)
not checked Klinisk prövning, fas IV (Clinical Trial Phase IV)
not checked Icke interventionsstudie
not checked Kontrollerade kliniska prövningar (Controlled Clinical Trial)
checked Randomiserad klinisk prövning (Randomized Controlled Trial)
not checked Multicenter studie
not checked Akademisk studie
not checked Annat

Sponsornamn

Fresenius Medical Care

EudraCT nummer

CIV-17-01-018204

Annat nummer, motsvarande EudraCT

UF-HF-02-INT

Status

checked Projektet pågår
not checked Projektet avslutat

PURE-HF, from Centrum för Klinisk Forskning Dalarna
http://www.researchweb.org/is/en/ckfuu/project/254341